The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2016

Filed:

Dec. 19, 2011
Applicants:

Christopher W. Boyce, Flemington, NJ (US);

Sylvia Joanna Degrado, Scotch Plains, NJ (US);

Xiao Chen, Edison, NJ (US);

Jun Qin, Edison, NJ (US);

Robert D. Mazzola, Jr., Stewartsville, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Kevin D. Mccormick, Basking Ridge, NJ (US);

Anandan Palani, Bridgewater, NJ (US);

Dong Xiao, Warren, NJ (US);

Robert George Aslanian, Rockaway, NJ (US);

Jie Wu, Scotch Plains, NJ (US);

Ashwin Umesh Rao, Morganville, NJ (US);

Phieng Siliphaivanh, Newton, MA (US);

Joey L. Methot, Westwood, MA (US);

Hongjun Zhang, Newton, MA (US);

Elizabeth Helen Kelley, Lynnfield, MA (US);

William Colby Brown, Cleveland Heights, OH (US);

Qin Jiang, Latham, NY (US);

Jolicia Polivina Gauuan, Schenectady, NY (US);

Andrew J. Leyhane, Latham, NY (US);

Purakkattle Johny Biju, Piscataway, NJ (US);

Pawan K. Dhondi, Elizabeth, NJ (US);

LI Dong, Lawrenceville, NJ (US);

Salem Fevrier, Cranford, NJ (US);

Xianhai Huang, Warren, NJ (US);

Henry M. Vaccaro, South Plainfield, NJ (US);

Inventors:

Christopher W. Boyce, Flemington, NJ (US);

Sylvia Joanna Degrado, Scotch Plains, NJ (US);

Xiao Chen, Edison, NJ (US);

Jun Qin, Edison, NJ (US);

Robert D. Mazzola, Jr., Stewartsville, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Kevin D. McCormick, Basking Ridge, NJ (US);

Anandan Palani, Bridgewater, NJ (US);

Dong Xiao, Warren, NJ (US);

Robert George Aslanian, Rockaway, NJ (US);

Jie Wu, Scotch Plains, NJ (US);

Ashwin Umesh Rao, Morganville, NJ (US);

Phieng Siliphaivanh, Newton, MA (US);

Joey L. Methot, Westwood, MA (US);

Hongjun Zhang, Newton, MA (US);

Elizabeth Helen Kelley, Lynnfield, MA (US);

William Colby Brown, Cleveland Heights, OH (US);

Qin Jiang, Latham, NY (US);

Jolicia Polivina Gauuan, Schenectady, NY (US);

Andrew J. Leyhane, Latham, NY (US);

Purakkattle Johny Biju, Piscataway, NJ (US);

Pawan K. Dhondi, Elizabeth, NJ (US);

Li Dong, Lawrenceville, NJ (US);

Salem Fevrier, Cranford, NJ (US);

Xianhai Huang, Warren, NJ (US);

Henry M. Vaccaro, South Plainfield, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 241/38 (2006.01); C07D 241/42 (2006.01); A61K 31/498 (2006.01); A61K 31/506 (2006.01); A61K 31/4985 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 451/02 (2006.01); C07D 471/08 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07D 403/06 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01); C07D 403/12 (2006.01); C07D 401/06 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 413/06 (2006.01); C07D 241/44 (2006.01); C07D 417/14 (2006.01); C07D 491/048 (2006.01); C07D 498/10 (2006.01);
U.S. Cl.
CPC ...
C07D 241/42 (2013.01); A61K 31/498 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 241/44 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 451/02 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 491/048 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01); C07D 498/10 (2013.01); C07D 241/38 (2013.01);
Abstract

The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J, J, R, R, R, R, R, R, R, R, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTHfunction.


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