The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2016
Filed:
Sep. 20, 2012
Applicant:
Brown University, Providence, RI (US);
Inventors:
Jeffrey R. Morgan, Sharon, MA (US);
Toni-Marie Achilli, Providence, RI (US);
Anubhav Tripathi, Northborough, MA (US);
Stephanie McCalla, Providence, RI (US);
Assignee:
Brown University, Providence, RI (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); G01N 33/5011 (2013.01);
Abstract
Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the spheroids. Uptake of a substrate of the efflux pump and distribution of a substrate for the efflux pump within the spheroids is imaged to thereby select drugs that inhibit the efflux pump or do not block gap junction communication. Selected drugs can then be employed to treat a tumor.