The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2016
Filed:
Sep. 10, 2012
Philip W. Landfield, Lexington, KY (US);
John Christopher Gant, Lexington, KY (US);
Eric M. Blalock, Lexington, KY (US);
Kuey-chu Chen, Lexington, KY (US);
Olivier Thibault, Lexington, KY (US);
Nada Porter, Lexington, KY (US);
Philip W. Landfield, Lexington, KY (US);
John Christopher Gant, Lexington, KY (US);
Eric M. Blalock, Lexington, KY (US);
Kuey-Chu Chen, Lexington, KY (US);
Olivier Thibault, Lexington, KY (US);
Nada Porter, Lexington, KY (US);
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, Lexington, KY (US);
Abstract
The subject technology relates, in part, to a method of treating Alzheimer's Disease (AD), early-stage AD, elevated risk of AD, mild cognitive impairment (MCI), or other forms of age-related cognitive decline in a subject in need thereof by administering to the subject a molecule that promotes calcium-release stabilization in ryanodine receptors (RyRs) and/or inosital triphosphate receptors (InsP3Rs) in brain cells. Diagnostic methods using calcium-release stabilizing immunophilins, junctophilins or calmodulin are also disclosed.