The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2016
Filed:
May. 02, 2014
Applicant:
E3x Bio, Menlo Park, CA (US);
Inventors:
Brigit Riley, Mill Valley, CA (US);
Jennifer Johnston, Mill Valley, CA (US);
David Morgans, Los Altos, CA (US);
Assignee:
E3X Bio, Inc., Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/37 (2006.01); C12Q 1/25 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/25 (2013.01); G01N 2333/9015 (2013.01); G01N 2500/02 (2013.01);
Abstract
The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease.