The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2016
Filed:
Aug. 01, 2013
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Jyoti Asundi, Foster City, CA (US);
Suzanna Clark, Pacificia, CA (US);
Paul Polakis, Mill Valley, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); A61K 47/48 (2006.01); A61K 31/551 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/3053 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); A61K 47/48384 (2013.01); A61K 47/48407 (2013.01); A61K 47/48561 (2013.01); A61K 47/48623 (2013.01); A61K 47/48715 (2013.01); C07K 16/2869 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/73 (2013.01);
Abstract
The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.