The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2016
Filed:
Nov. 01, 2013
Applicants:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Loren D. Walensky, Chestnut Hill, MA (US);
Stanley J. Korsmeyer, Weston, MA (US);
Gregory Verdine, Lexington, MA (US);
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/50 (2006.01); C07K 14/435 (2006.01); C07K 7/64 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 1/113 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); C07K 1/113 (2013.01); C07K 14/001 (2013.01); C07K 14/435 (2013.01); C07K 14/4747 (2013.01); A61K 38/00 (2013.01);
Abstract
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ('hydrocarbon stapling') moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.