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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9464077 B1

PDFFull Text
Date of Patent:
Oct. 11, 2016

Filed:

Feb. 26, 2013

Nitrogen-containing aromatic heterocyclic compound

Applicants:

Astellas Pharma Inc., Tokyo, JP;

Kotobuki Pharmaceutical Co., Ltd., Nagano, JP;

Inventors:

Minoru Kameda, Tokyo, JP;

Ikumi Kuriwaki, Tokyo, JP;

Kazuhiko Iikubo, Tokyo, JP;

Hiroyuki Hisamichi, Tokyo, JP;

Yuichiro Kawamoto, Tokyo, JP;

Hiroyuki Moritomo, Tokyo, JP;

Tomoyuki Suzuki, Tokyo, JP;

Takashi Futami, Tokyo, JP;

Atsushi Suzuki, Tokyo, JP;

Kazuhisa Tsunoyama, Tokyo, JP;

Makoto Asaumi, Tokyo, JP;

Hiroshi Tomiyama, Nagano, JP;

Atsushi Noda, Nagano, JP;

Yoshinori Iwai, Nagano, JP;

Kazuo Tokuzaki, Nagano, JP;

Haruki Okada, Nagano, JP;

Kozo Miyasaka, Nagano, JP;

Assignees:

Astellas Pharma Inc., Tokyo, JP;

KOTOBUKI PHARMACEUTICAL CO., LTD., Nagano, JP;

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P.

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
C07D 413/12 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 401/12 (2006.01); C07D 239/42 (2006.01); C07D 239/47 (2006.01); C07D 471/10 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 451/02 (2006.01); C07D 451/04 (2006.01); C07D 453/02 (2006.01); C07D 487/10 (2006.01); C07D 491/107 (2006.01); A61K 31/506 (2006.01);
U.S. Cl.
CPC ...
C07D 413/12 (2013.01); C07D 239/42 (2013.01); C07D 239/47 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 451/02 (2013.01); C07D 451/04 (2013.01); C07D 453/02 (2013.01); C07D 471/10 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01);
Abstract

Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

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