The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2016

Filed:

Sep. 07, 2012
Applicants:

Jeffrey Aube, Lawrence, KS (US);

Brian Scott Jonathan Blagg, Lawrence, KS (US);

Kevin John Frankowski, Lawrence, KS (US);

David Norman Frick, Bayside, WI (US);

Kelin LI, Lawrence, KS (US);

Frank John Schoenen, Lawrence, KS (US);

Inventors:

Jeffrey Aube, Lawrence, KS (US);

Brian Scott Jonathan Blagg, Lawrence, KS (US);

Kevin John Frankowski, Lawrence, KS (US);

David Norman Frick, Bayside, WI (US);

Kelin Li, Lawrence, KS (US);

Frank John Schoenen, Lawrence, KS (US);

Assignees:

University of Kansas, Lawrence, KS (US);

UWM Research Foundation, Inc., Milwaukee, WI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 277/66 (2006.01); A61K 45/06 (2006.01); A61K 31/13 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/7056 (2006.01); C12Q 1/68 (2006.01); G01N 1/30 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07D 277/66 (2013.01); A61K 31/13 (2013.01); A61K 31/428 (2013.01); A61K 31/4439 (2013.01); A61K 31/7056 (2013.01); A61K 45/06 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C12Q 1/6806 (2013.01); G01N 1/30 (2013.01); G01N 33/6896 (2013.01); C12Q 2563/173 (2013.01); G01N 2001/302 (2013.01);
Abstract

The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are useful as antiviral agents. The present invention further relates to pharmaceutical compositions containing the aforementioned compounds and methods of treating an HCV infection.


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