The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2016
Filed:
Oct. 11, 2011
Johan Lub, Valkenswaard, NL;
Wolter Ten Hoeve, Assen, NL;
Raffaella Rossin, Eindhoven, NL;
Sandra Martina Van Den Bosch, Weert, NL;
Marc Stefan Robillard, Eindhoven, NL;
Johan Lub, Valkenswaard, NL;
Wolter Ten Hoeve, Assen, NL;
Raffaella Rossin, Eindhoven, NL;
Sandra Martina Van Den Bosch, Weert, NL;
Marc Stefan Robillard, Eindhoven, NL;
KONINKLIJKE PHILIPS N.V., Eindhoven, NL;
Abstract
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.