The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2016
Filed:
Jan. 28, 2014
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Mahidol University, Nakhon Pathom, TH;
Richard M. Kinney, Fort Collins, CO (US);
Claire Y. H. Kinney, Fort Collins, CO (US);
Siritorn Butrapet, Bangkok, TH;
Duane J. Gubler, St. George, UT (US);
Natth Bhamarapravati, Bangkok, TH;
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Mahidol University, Nakhon Pathom, TH;
Abstract
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.