The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2016
Filed:
Dec. 02, 2009
Applicant:
Hugo Daniel Lujan, Córdoba, AR;
Inventor:
Hugo Daniel Lujan, Córdoba, AR;
Assignee:
Universidad Catolica de Cordoba, Cordoba, AR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/10 (2006.01); C12N 1/00 (2006.01); A61K 39/00 (2006.01); A01N 63/00 (2006.01); A61K 48/00 (2006.01); A61K 39/002 (2006.01); A61K 35/68 (2006.01); C07K 14/44 (2006.01); C07K 16/20 (2006.01); C12N 15/86 (2006.01); A61K 38/00 (2006.01); C12N 1/20 (2006.01);
U.S. Cl.
CPC ...
A61K 39/002 (2013.01); A61K 35/68 (2013.01); C07K 14/44 (2013.01); C07K 16/20 (2013.01); A61K 38/00 (2013.01); A61K 2039/522 (2013.01); A61K 2039/542 (2013.01); A61K 2039/552 (2013.01); C12N 1/10 (2013.01); C12N 1/20 (2013.01); C12N 15/86 (2013.01);
Abstract
Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.