The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2016
Filed:
Mar. 06, 2014
Merrimack Pharmaceuticals, Inc., Cambridge, MA (US);
Brian Harms, Roslindale, MA (US);
Neeraj Kohli, Brighton, MA (US);
Alexey Lugovskoy, Woburn, MA (US);
Melissa Geddie, Somerville, MA (US);
Eric Mark Krauland, Lebanon, NH (US);
William George Roach, Lebanon, NH (US);
Stephen Su, Boston, MA (US);
Adnan Abu-Yousif, Boston, MA (US);
Merrimack Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
Provided herein are tandem Fcs and tandem Fc antibodies ('TFcAs'), e.g., tandem Fc bispecific antibodies ('TFcBAs'), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs bind to the cell surface receptors c-Met and EpCam and inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.