The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 04, 2016

Filed:

Oct. 16, 2013
Applicant:

Genmab A/s, Copenhagen, DK;

Inventors:

Jan G. J. Van De Winkel, Zeist, NL;

Marcus Antonius Van Dijk, Bilthoven, NL;

Edward Halk, Sunnyvale, CA (US);

Arnout F. Gerritsen, Bunnik, NL;

Jørgen Petersen, Rungsted Kyst, DK;

Ole Baadsgaard, Hellerup, DK;

Assignee:

GENMAB A/S, Copenhagen, DK;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07H 21/04 (2006.01); G01N 33/53 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/48561 (2013.01); G01N 33/56966 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.


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