The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2016
Filed:
Nov. 19, 2014
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Gerald B. Pier, Brookline, MA (US);
Casie Anne Kelly-Quintos, Costa Mesa, CA (US);
Lisa Cavacini, Natick, MA (US);
Marshall R. Posner, Mount Vernon, NY (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Abstract
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such asPNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited toand. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited toand. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.