The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2016
Filed:
May. 27, 2014
The United States of America As Represented BY the Department of Veterans Affairs, Washington, DC (US);
Loma Linda University, Loma Linda, CA (US);
Kin-Hing William Lau, Redlands, CA (US);
Susan L. Hall, San Bernardino, CA (US);
Shin-Tai Chen, Colton, CA (US);
Subburaman Mohan, Redlands, CA (US);
David J. Baylink, Redlands, CA (US);
Loma Linda University, Loma Linda, CA (US);
The United States of America as represented by the Department of Veteran Affairs, Washington, DC (US);
Abstract
The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).