The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2016
Filed:
Dec. 19, 2011
James Alan Kerschen, Somerset, NJ (US);
Alexander James Bridges, Saline, MI (US);
Milind D. Choubal, Mundelein, IL (US);
Sean Mark Dalziel, San Francisco, CA (US);
Thomas Elliott Jacks, Hillsborough, NJ (US);
Andrew S. Thompson, Mountainside, NJ (US);
James Robert Zeller, Scottsdale, AZ (US);
James Alan Kerschen, Somerset, NJ (US);
Alexander James Bridges, Saline, MI (US);
Milind D. Choubal, Mundelein, IL (US);
Sean Mark Dalziel, San Francisco, CA (US);
Thomas Elliott Jacks, Hillsborough, NJ (US);
Andrew S. Thompson, Mountainside, NJ (US);
James Robert Zeller, Scottsdale, AZ (US);
BTG INTERNATIONAL LIMITED, London, GB;
Abstract
A new method for the synthesis of L-Glutamyl-γ-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.