The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2016
Filed:
May. 23, 2013
Applicant:
Stemergie Biotechnology SA, Geneva, CH;
Inventors:
Virginie Clement-Schatlo, Suhr, CH;
Thomas Fessard, Zürich, CH;
Damien Barbaras, Baar, CH;
Joana Matos, Zürich, CH;
Erick Carreira, Zumikon, CH;
Assignee:
Stemergie Biotechnology SA, Geneva, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/41 (2006.01); C07D 495/10 (2006.01); C07D 213/81 (2006.01); C07D 215/28 (2006.01); C07C 275/42 (2006.01); C07C 39/30 (2006.01); C07D 231/56 (2006.01); C07C 311/08 (2006.01); C07D 235/26 (2006.01); C07D 405/12 (2006.01); C07C 215/50 (2006.01); C07D 249/06 (2006.01); C07C 233/25 (2006.01); C07D 263/32 (2006.01); C07D 263/34 (2006.01); C07D 487/10 (2006.01); C07C 237/38 (2006.01); C07C 237/42 (2006.01); C07C 251/48 (2006.01); C07D 209/42 (2006.01); C07D 305/06 (2006.01); C07C 49/825 (2006.01); C07D 403/12 (2006.01); C07D 223/28 (2006.01); C07D 235/18 (2006.01); C07C 233/33 (2006.01); C07D 261/08 (2006.01); C07C 235/60 (2006.01); C07C 235/62 (2006.01); C07D 263/57 (2006.01); C07D 491/107 (2006.01); C07C 237/40 (2006.01); C07C 237/44 (2006.01); C07D 277/56 (2006.01); C07D 513/10 (2006.01); C07D 305/08 (2006.01); A01N 31/08 (2006.01); A01N 33/10 (2006.01); A01N 35/04 (2006.01); A01N 37/24 (2006.01); A01N 37/40 (2006.01); A01N 37/44 (2006.01); A01N 37/46 (2006.01); A01N 37/50 (2006.01); A01N 43/20 (2006.01); A01N 43/38 (2006.01); A01N 43/40 (2006.01); A01N 43/42 (2006.01); A01N 43/46 (2006.01); A01N 43/52 (2006.01); A01N 43/56 (2006.01); A01N 43/60 (2006.01); A01N 43/647 (2006.01); A01N 43/76 (2006.01); A01N 43/78 (2006.01); A01N 43/80 (2006.01); A01N 43/90 (2006.01); A01N 47/30 (2006.01); C07C 39/24 (2006.01); C07C 43/178 (2006.01); C07C 49/245 (2006.01); A61K 31/137 (2006.01); A61K 31/167 (2006.01); A61K 31/17 (2006.01); A61K 31/18 (2006.01); A61K 31/397 (2006.01); A61K 31/421 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 223/24 (2006.01);
U.S. Cl.
CPC ...
C07D 495/10 (2013.01); A01N 31/08 (2013.01); A01N 33/10 (2013.01); A01N 35/04 (2013.01); A01N 37/24 (2013.01); A01N 37/40 (2013.01); A01N 37/44 (2013.01); A01N 37/46 (2013.01); A01N 37/50 (2013.01); A01N 43/20 (2013.01); A01N 43/38 (2013.01); A01N 43/40 (2013.01); A01N 43/42 (2013.01); A01N 43/46 (2013.01); A01N 43/52 (2013.01); A01N 43/56 (2013.01); A01N 43/60 (2013.01); A01N 43/647 (2013.01); A01N 43/76 (2013.01); A01N 43/78 (2013.01); A01N 43/80 (2013.01); A01N 43/90 (2013.01); A01N 47/30 (2013.01); A61K 31/137 (2013.01); A61K 31/167 (2013.01); A61K 31/17 (2013.01); A61K 31/18 (2013.01); A61K 31/397 (2013.01); A61K 31/421 (2013.01); A61K 31/44 (2013.01); A61K 31/47 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07C 39/245 (2013.01); C07C 39/30 (2013.01); C07C 43/1787 (2013.01); C07C 49/245 (2013.01); C07C 49/825 (2013.01); C07C 215/50 (2013.01); C07C 233/25 (2013.01); C07C 233/33 (2013.01); C07C 235/60 (2013.01); C07C 235/62 (2013.01); C07C 237/38 (2013.01); C07C 237/40 (2013.01); C07C 237/42 (2013.01); C07C 237/44 (2013.01); C07C 251/48 (2013.01); C07C 275/42 (2013.01); C07C 311/08 (2013.01); C07D 209/42 (2013.01); C07D 213/81 (2013.01); C07D 215/28 (2013.01); C07D 223/24 (2013.01); C07D 223/28 (2013.01); C07D 231/56 (2013.01); C07D 235/18 (2013.01); C07D 235/26 (2013.01); C07D 249/06 (2013.01); C07D 261/08 (2013.01); C07D 263/32 (2013.01); C07D 263/34 (2013.01); C07D 263/57 (2013.01); C07D 277/56 (2013.01); C07D 305/06 (2013.01); C07D 305/08 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 513/10 (2013.01); C07C 2101/04 (2013.01); C07C 2101/14 (2013.01); C07C 2101/18 (2013.01); C07C 2102/08 (2013.01); C07C 2102/42 (2013.01); C07C 2103/74 (2013.01);
Abstract
The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumor-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.