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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9458120 B1

PDFFull Text
Date of Patent:
Oct. 04, 2016

Filed:

Nov. 30, 2012

Phenoxypropanol derivative and pharmaceutical composition including the same

Applicant:

Korea Institute of Science and Technology, Seoul, KR;

Inventors:

Eun-Joo Roh, Seoul, KR;

Kye-Jung Shin, Seoul, KR;

Changjoon Justin Lee, Seoul, KR;

Soo Jin Oh, Seoul, KR;

Jung-Eun Park, Seoul, KR;

Jeong Eun Yang, Suwon-si, KR;

Eun Mi Hwang, Jinju-si, KR;

Dong Ho Woo, Seoul, KR;

Soon-Hyouk Lee, Daejeon, KR;

Dong-Gyu Kim, Gyeongsangnam-do, KR;

Hee-jung Chun, Seoul, KR;

Wan-Keun Ji, Seoul, KR;

Yun-Soo Na, Gyeonggi-do, KR;

Assignee:

KORBA INSTITUTE OF SCIENCE AND TECHNOLOGY, Seoul, KR;

Attorney:

Goldilocks Zone IP Law

Primary Examiner:

Emily Bernhardt

Int. Cl.
CPC ...
C07D 295/15 (2006.01); A61K 31/496 (2006.01); C07D 295/088 (2006.01); C07D 231/40 (2006.01); C07D 211/22 (2006.01); C07D 211/38 (2006.01); C07D 211/52 (2006.01); C07D 211/58 (2006.01); C07D 233/64 (2006.01); C12N 5/071 (2010.01); C07D 401/04 (2006.01); C07D 403/06 (2006.01); C07D 413/04 (2006.01); A61K 31/495 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C07D 295/15 (2013.01); C07D 211/22 (2013.01); C07D 211/38 (2013.01); C07D 211/52 (2013.01); C07D 211/58 (2013.01); C07D 231/40 (2013.01); C07D 233/64 (2013.01); C07D 295/088 (2013.01); C12N 5/0686 (2013.01); C12N 2501/999 (2013.01);
Abstract

The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

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