The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2016
Filed:
Jan. 15, 2014
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
David V. Schaffer, Danville, CA (US);
Ryan R. Klimczak, San Francisco, CA (US);
James T. Koerber, San Francisco, CA (US);
John G. Flannery, Berkeley, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/23 (2006.01); A61K 48/00 (2006.01); A01K 67/027 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 35/76 (2015.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0008 (2013.01); A01K 67/0275 (2013.01); A61K 35/76 (2013.01); A61K 38/179 (2013.01); A61K 38/185 (2013.01); A61K 38/1808 (2013.01); A61K 38/1825 (2013.01); A61K 48/0075 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0356 (2013.01); A61K 38/00 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14145 (2013.01); C12N 2810/855 (2013.01);
Abstract
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.