The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9457102 B1

PDF
Full Text
Expired
Date of Patent:
Oct. 04, 2016

Filed:

Apr. 25, 2012
Applicants:

Yoichi Negishi, Hachioji, JP;

Yoko Takahashi, Hachioji, JP;

Kazuo Maruyama, Itabashi-ku, JP;

Yukihiko Aramaki, Hachioji, JP;

Inventors:

Yoichi Negishi, Hachioji, JP;

Yoko Takahashi, Hachioji, JP;

Kazuo Maruyama, Itabashi-ku, JP;

Yukihiko Aramaki, Hachioji, JP;

Assignee:

NEPA GENE CO., LTD., Ichikawa-shi, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 41/00 (2006.01); A61K 9/00 (2006.01); A61K 47/24 (2006.01); A61K 9/127 (2006.01); C12N 15/88 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/48815 (2013.01); A61K 9/0019 (2013.01); A61K 9/1271 (2013.01); A61K 41/0028 (2013.01); A61K 41/0047 (2013.01); A61K 47/24 (2013.01); C12N 15/113 (2013.01); C12N 15/88 (2013.01); C12N 2310/11 (2013.01); C12N 2310/3233 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/32 (2013.01); C12N 2320/33 (2013.01);
Abstract

To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.


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Negishi, Yoichi. (2016). Therapeutic muscular dystrophy drug having bubble liposome loaded with morpholino as active ingredient (U.S. Patent No. 9457102). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9457102

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