The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9456998 B1

PDF
Full Text
Expired
Date of Patent:
Oct. 04, 2016

Filed:

May. 22, 2013
Applicants:

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;

Hoffmann-la Roche Inc., Nutley, NJ (US);

Inventors:

Uri Ben-David, Jerusalem, IL;

Nissim Benvenisty, Jerusalem, IL;

Payal Arora, Bridgewater, NJ (US);

Qing-Fen Gan, Palo Alto, CA (US);

Ralph J. Garippa, Roseland, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4409 (2006.01); A61K 31/15 (2006.01); A61K 31/34 (2006.01); A61K 31/403 (2006.01); A61K 31/407 (2006.01); A61K 31/4453 (2006.01); A61K 31/4545 (2006.01); A61K 31/4985 (2006.01); A61K 31/136 (2006.01); A61K 31/155 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/341 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/4015 (2006.01); A61K 31/404 (2006.01); A61K 31/451 (2006.01); A61K 31/513 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 31/15 (2013.01); A61K 31/136 (2013.01); A61K 31/155 (2013.01); A61K 31/165 (2013.01); A61K 31/166 (2013.01); A61K 31/34 (2013.01); A61K 31/341 (2013.01); A61K 31/343 (2013.01); A61K 31/381 (2013.01); A61K 31/403 (2013.01); A61K 31/404 (2013.01); A61K 31/407 (2013.01); A61K 31/4015 (2013.01); A61K 31/4409 (2013.01); A61K 31/4453 (2013.01); A61K 31/451 (2013.01); A61K 31/4545 (2013.01); A61K 31/4985 (2013.01); A61K 31/513 (2013.01); G01N 33/502 (2013.01); G01N 33/5073 (2013.01); G01N 2500/02 (2013.01); G01N 2500/10 (2013.01);
Abstract

Uses of a compound of any of Formulas I-VI as a cytotoxic inhibitor of undifferentiated cells are disclosed herein, as well as pharmaceutical compositions comprising a compound of any of Formulas I-VI, and methods for identifying a lead candidate for inhibiting undifferentiated cells. Further disclosed are uses of an SCD-1 inhibitor as a cytotoxic inhibitor of undifferentiated cells.


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