The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2016
Filed:
Apr. 16, 2013
Applicants:
Eli Lilly and Company, Indianapolis, IN (US);
Washington University, St. Louis, MO (US);
Inventors:
David M. Holtzman, St. Louis, MO (US);
Ronald DeMattos, Noblesville, IN (US);
Kelly R. Bales, Coatsville, IN (US);
David J. Cummins, Indianapolis, IN (US);
Steven M. Paul, Carmel, IN (US);
Assignees:
ELI LILLY AND COMPANY, Indianapolis, IN (US);
WASHINGTON UNIVERSITY, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/577 (2006.01); C07K 16/18 (2006.01); A61K 39/395 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); G01N 33/6896 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/41 (2013.01); C07K 2317/56 (2013.01); C07K 2317/92 (2013.01); G01N 2800/2821 (2013.01);
Abstract
A diagnostic test for preclinical and clinical Alzheimer's disease is based on plasma levels of Aβ, Aβ, their ratio, or their rate of entry following administration of antibodies that sequester Aβ. Alterations of any of these parameters from control values identifies preclinical or clinical Alzheimer's disease.