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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9453062 B1

PDFFull Text
Date of Patent:
Sep. 27, 2016

Filed:

Jun. 08, 2012

Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof

Applicants:

Tao MA, Beijing, CN;

Shusen Xu, Beijing, CN;

Zhijun Liu, Beijing, CN;

BO Zhang, Beijing, CN;

Ning Shen, Beijing, CN;

Hai Yang, Beijing, CN;

Wei Zhang, Beijing, CN;

Yuhua LI, Beijing, CN;

Sunghwan Moon, Hwaseong-Si, KR;

Maengsup Kim, Beijing, CN;

Inventors:

Tao Ma, Beijing, CN;

Shusen Xu, Beijing, CN;

Zhijun Liu, Beijing, CN;

Bo Zhang, Beijing, CN;

Ning Shen, Beijing, CN;

Hai Yang, Beijing, CN;

Wei Zhang, Beijing, CN;

Yuhua Li, Beijing, CN;

Sunghwan Moon, Hwaseong-Si, KR;

Maengsup Kim, Beijing, CN;

Assignee:

Beijing Hanmi Pharmaceutical Co., Ltd., Beijing, CN;

Attorneys:

Fox Rothschild LLP

Jianming Jimmy Hao

Primary Examiner:

James H Alstrum Acevedo

Assistant Examiner:

Thea D'Ambrosio

Int. Cl.
CPC ...
A61K 38/22 (2006.01); A61K 38/00 (2006.01); A61K 38/28 (2006.01); A61K 38/26 (2006.01); A61K 38/16 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 7/12 (2006.01); A61P 19/10 (2006.01); C07K 14/605 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 14/575 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/575 (2013.01); A61K 38/16 (2013.01); A61K 38/22 (2013.01); C07K 14/00 (2013.01); C07K 14/605 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.

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