The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2016
Filed:
Aug. 11, 2014
Applicant:
New York University, New York, NY (US);
Inventors:
Jin Kim Montclare, New York, NY (US);
Haresh T. More, Ozone Park, NY (US);
Joseph Frezzo, Brooklyn, NY (US);
Carlo Yuvienco, New York, NY (US);
Assignee:
New York University, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 47/42 (2006.01); A61K 48/00 (2006.01); A61K 9/127 (2006.01); A61K 9/00 (2006.01); C12N 15/113 (2010.01); A61K 47/10 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61K 9/0014 (2013.01); A61K 9/127 (2013.01); A61K 47/10 (2013.01); A61K 47/42 (2013.01); A61K 48/0025 (2013.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract
Provided are compositions and methods for efficient delivery of polynucleotides and/or small molecules to or into cells. The compositions comprises a peptide which as an excess positive charge and self assembles into homopentamers. The homopentamers can non-covalently bind polynucleotides. When encapsulated in lipid systems, such as liposomes, the lipoproteoplexes so formed, are capable of delivering both nucleic acids and small molecules to cells.