The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2016
Filed:
Dec. 14, 2012
Board of Regents, the University of Texas System, Austin, TX (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Florian L. Muller, Houston, TX (US);
Eliot Fletcher-Sananikone, Houston, TX (US);
Simona Colla, Houston, TX (US);
Elisa Aquilanti, Boston, MA (US);
Ronald DePinho, Houston, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor.