The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 27, 2016

Filed:

Nov. 05, 2012
Applicant:

Galderma Research & Development, Biot, FR;

Inventor:

Cédric Poinsard, Le Rouret, FR;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/75 (2006.01); A61K 31/44 (2006.01); A61K 8/49 (2006.01); C07D 213/81 (2006.01); A61Q 7/00 (2006.01); C07D 405/12 (2006.01); C07D 239/52 (2006.01); C07D 239/48 (2006.01); A61Q 7/02 (2006.01); A61K 8/69 (2006.01); A61Q 19/00 (2006.01); C07D 213/79 (2006.01); C07D 213/84 (2006.01); C07D 239/47 (2006.01); A61Q 5/00 (2006.01);
U.S. Cl.
CPC ...
A61K 8/498 (2013.01); A61K 8/4926 (2013.01); A61K 8/4953 (2013.01); A61K 8/69 (2013.01); A61Q 5/008 (2013.01); A61Q 7/00 (2013.01); A61Q 7/02 (2013.01); A61Q 19/008 (2013.01); C07D 213/75 (2013.01); C07D 213/79 (2013.01); C07D 213/81 (2013.01); C07D 213/84 (2013.01); C07D 239/47 (2013.01); C07D 239/48 (2013.01); C07D 239/52 (2013.01); C07D 405/12 (2013.01);
Abstract

N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides of formula (1) are described that are potent modulators (e.g., inhibitors) of an androgen receptor, and which are useful, for example, in the treatment of a dermatological disease or disorder; a disease or disorder of the sebaceous gland(s); acne; hyperseborrhoea; oily skin, seborrhoeic dermatitis; hyperpilosity or hirsutism; atopic dermatitis; or androgenic alopecia; especially acne. Also described, are compositions (e.g., pharmaceutical compositions, cosmetic compositions) comprising the compounds; methods of preparing the compositions; methods of modulating (e.g., inhibiting) and androgen receptors using the compounds and/or compositions; and medical and/or cosmetic use of the compounds and compositions.


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