The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2016
Filed:
May. 18, 2012
Robby Ruijtenbeek, Utrecht, NL;
Jeroen Van Ameijde, Utrecht, NL;
Robertus Matthias Joseph Liskamp, Utrecht, NL;
Robby Ruijtenbeek, Utrecht, NL;
Jeroen van Ameijde, Utrecht, NL;
Robertus Matthias Joseph Liskamp, Utrecht, NL;
PAMGENE B.V., 'S-Hertogenbosch, NL;
UNIVERSITEIT UTRECHT HOLDING B.V., Utrecht, NL;
Abstract
The present invention relates to a method and tools which allow the kinetic monitoring of hydrolase enzyme activity. The present invention also aims to provide synthetic peptides and peptide residues modified such that they can be used in assays for monitoring hydrolase enzyme activity, and preferably phosphatase activity. Also claimed are modified tyrosine amino acid derivatives of formula (IV), wherein Y is chosen from —POwith y equal to 2 or 3 and esters thereof, —SOwith z equal to 2 or 3 and esters thereof, a carbohydrate or carbohydrate derivatives; and; wherein Xand/or Xis selected from —N, —NO, —CI, or —CN, —SCN, a Cto Calkyl, or H, wherein either Xor Xis not H.