The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2016
Filed:
Feb. 21, 2014
Applicants:
Jian Chen, Wuxi, CN;
Hongwei Guo, Wuxi, CN;
Jingwen Zhou, Wuxi, CN;
Guocheng Du, Wuxi, CN;
Inventors:
Assignee:
Jiangnan University, Wuxi, JS, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/14 (2006.01); C12P 7/40 (2006.01); C12N 15/00 (2006.01); C07H 21/02 (2006.01); C07K 1/00 (2006.01); C12N 15/81 (2006.01); C12N 1/16 (2006.01); C07K 14/195 (2006.01);
U.S. Cl.
CPC ...
C12P 7/40 (2013.01); C07K 14/195 (2013.01); C12N 1/16 (2013.01); C12N 15/815 (2013.01);
Abstract
The present invention provides a genetically engineeredwith enhanced extracellular secretion of pyruvic acid.strain was obtained from China Center for Type Culture Collection with CCTCC No: M202019 and over-expressed the optimized CutA (SEQ ID NO:2) encoding stress protein. Both of the temperature tolerance ofand extracellular concentration of pyruvate were improved by overexpressing the optimized CutA. The optimum growth temperature of genetically engineeredwas increased too. The present invention can be widely used to increase extracellular levels of pyruvate during the fermentation process.