The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2016
Filed:
Mar. 10, 2008
Applicants:
David Bates, Bristol, GB;
Steven James Harper, Bristol, GB;
Dawid Grzegorz Nowak, Bristol, GB;
Inventors:
Assignee:
UNIVERSITY OF BRISTOL, Bristol, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); C12N 15/113 (2010.01); A61K 31/535 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1136 (2013.01); A61K 31/535 (2013.01); C12N 2310/11 (2013.01); C12N 2310/3233 (2013.01); C12N 2320/33 (2013.01);
Abstract
The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.