The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2016
Filed:
Feb. 03, 2012
Yi Wang, Woodbridge, CT (US);
Susan Faas Mcknight, Old Lyme, CT (US);
Zhao Xue Yu, Cheshire, CT (US);
Hao Wang, London, CA;
Yi Wang, Woodbridge, CT (US);
Susan Faas McKnight, Old Lyme, CT (US);
Zhao Xue Yu, Cheshire, CT (US);
Hao Wang, London, CA;
Alexion Pharmaceuticals, Inc., New Haven, CT (US);
Abstract
The present disclosure provides methods useful for prolonging the survival of an allograft organ in a recipient mammal. The methods include administration of an anti-CD200 antibody or a CD200-binding fragment of the antibody. The disclosure also provides biomarkers, a change in one or more of which indicates that an anti-CD200 antibody has produced a desired immunomodulatory effect in a mammal. Also featured are pharmaceutical compositions, kits, and solutions that contain at least one anti-CD200 antibody and are useful in the methods described herein.