The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2016
Filed:
Jul. 06, 2009
Applicants:
James Anthony Clarke, Oxford, GB;
Lakmal Jayasinghe, Oxford, GB;
Terence Reid, Oxford, GB;
John Hagan Pryce Bayley, Oxford, GB;
Inventors:
James Anthony Clarke, Oxford, GB;
Lakmal Jayasinghe, Oxford, GB;
Terence Reid, Oxford, GB;
John Hagan Pryce Bayley, Oxford, GB;
Assignee:
Oxford Nanopore Technologies Limited, Oxford, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C07K 14/245 (2006.01);
U.S. Cl.
CPC ...
C07K 14/245 (2013.01); C12Q 1/6869 (2013.01);
Abstract
The invention relates to a mutant α-hemolysin (α-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is particularly useful for sequencing DNA or RNA. A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore. The pore is specifically modified to facilitate positioning of the adaptor and may be modified to facilitate covalent attachment.