The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2016
Filed:
Aug. 19, 2013
Brandeis University, Waltham, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Lizbeth K. Hedstrom, Newton, MA (US);
Gregory D. Cuny, Houston, TX (US);
Suresh K. Gorla, Gurgaon, IN;
Mandapati Kavitha, Gurgaon, IN;
Brandeis University, Waltham, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound selectively inhibits a parasitic IMPDH versus a host IMPDH. Also disclosed are pharmaceutical compositions comprising one or more compounds of the invention. Related methods of treating various parasitic and bacterial infections in mammals are disclosed. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.