The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2016
Filed:
Jul. 21, 2015
Applicant:
Daiichi Sankyo Company, Limited, Chuo-ku, Tokyo, JP;
Inventors:
Assignee:
Daiichi Sankyo Company, Limited, Chuo-ku, JP;
Primary Examiner:
Int. Cl.
CPC ...
C07D 513/04 (2006.01); A61K 31/444 (2006.01); C07C 271/24 (2006.01); C07C 303/28 (2006.01); C07C 303/34 (2006.01); C07C 307/08 (2006.01); C07B 53/00 (2006.01); C07C 309/66 (2006.01); C07C 309/73 (2006.01); C07D 285/14 (2006.01); C07C 303/40 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/444 (2013.01); C07B 53/00 (2013.01); C07C 271/24 (2013.01); C07C 303/28 (2013.01); C07C 303/34 (2013.01); C07C 303/40 (2013.01); C07C 307/08 (2013.01); C07C 309/66 (2013.01); C07C 309/73 (2013.01); C07D 285/14 (2013.01);
Abstract
The problem to be solved is to provide a method for efficiently producing compounds (1) and (1a) that are important intermediate compounds in the production of FXa inhibitors (X) and (X-a). The solutions thereto are a method for producing a compound represented by the formula (8d) using a stereoselective intramolecular cyclization reaction, and a method for producing a compound (1f) or a salt thereof, or a hydrate thereof, which is characterized by desulfonylation of the compound (8d). In each formula, Rrepresents a C1-C6 alkyl group, a benzyl group, etc.