The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 20, 2016

Filed:

Jun. 21, 2013
Applicant:

Cancer Research Technology Limited, London, GB;

Inventors:

Julian Blagg, Sutton, GB;

Vassilios Bavetsias, Sutton, GB;

Andrew S. Moore, Herston, AU;

Spyridon Linardopoulos, Sutton, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/496 (2006.01); C07D 471/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 471/06 (2013.01);
Abstract

The present invention relates to compounds of formula I: wherein Rand Rare as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The compounds of formula I are inhibitors of aurora kinase and/or FLT3. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which aurora kinase and/or FLT3 activity is implicated.


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