The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 20, 2016

Filed:

Jan. 06, 2014
Applicant:

Askat Inc., Aichi, JP;

Inventors:

Yoshiyuki Okumura, Aichi, JP;

Yasuhiro Iwata, Aichi, JP;

Toyoharu Numata, Aichi, JP;

Masaki Sudo, Aichi, JP;

Takako Okumura, Aichi, JP;

Assignee:

AskAt Inc., Aichi, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/48 (2006.01); C07D 311/58 (2006.01); C07C 215/10 (2006.01);
U.S. Cl.
CPC ...
C07D 311/58 (2013.01); A61K 9/4825 (2013.01); C07C 215/10 (2013.01); C07B 2200/13 (2013.01);
Abstract

This invention relates to salts and crystal forms of (S)-6-chloro-7-(1,1-dimethylethyl)-2-trifluoromethyl-2H-1-benzopyran-3-carboxylic acid, Compound A, which is cyclooxygenase-2 inhibitor. The present invention provides a salt of compound A, a crystal form thereof, a process for preparing the said salt and a pharmaceutical composition thereof and its use. The salts and/or co-crystals of Compound A of the present invention show good formulation properties such as high aqueous solubility, good intrinsic dissolution, good crystallinity, good thermal stability or low hygroscopicity.


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