The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 20, 2016

Filed:

Oct. 30, 2015
Applicant:

Carbylan Therapeutics, Inc., Palo Alto, CA (US);

Inventors:

David M. Gravett, Mountain View, CA (US);

George Y. Daniloff, Los Altos, CA (US);

Pingren He, Sunnyvale, CA (US);

Assignee:

Carbylan Therapeutics, Inc., Newark, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/36 (2006.01); A61K 31/58 (2006.01); A61K 9/14 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/36 (2013.01); A61K 9/0019 (2013.01); A61K 9/14 (2013.01); A61K 31/58 (2013.01);
Abstract

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.


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