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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9446050 B1

PDFFull Text
Expired
Date of Patent:
Sep. 20, 2016

Filed:

Oct. 24, 2012

Method for treatment of mesothelioma

Applicant:

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Inventors:

Raphael Bueno, Brookline, MA (US);

David Sugarbaker, Milton, MA (US);

Assignee:

THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US);

Attorneys:

Nixon Peabody LLP

David S. Resnick

Tari W. Mills

Primary Examiner:

Dennis Heyer

Int. Cl.
CPC ...
A61K 31/565 (2006.01); A61K 31/519 (2006.01); A61K 33/24 (2006.01); A61K 31/282 (2006.01); G01N 33/68 (2006.01); C12Q 1/68 (2006.01); A61K 31/566 (2006.01); A61K 31/567 (2006.01); A61K 45/06 (2006.01); A61K 31/555 (2006.01); A61K 31/56 (2006.01); A61K 31/58 (2006.01); G01N 33/574 (2006.01); G06F 19/00 (2011.01);
U.S. Cl.
CPC ...
A61K 31/565 (2013.01); A61K 31/282 (2013.01); A61K 31/519 (2013.01); A61K 31/555 (2013.01); A61K 31/56 (2013.01); A61K 31/566 (2013.01); A61K 31/567 (2013.01); A61K 31/58 (2013.01); A61K 33/24 (2013.01); A61K 45/06 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57407 (2013.01); G01N 33/6872 (2013.01); G06F 19/34 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The present invention provides that Ras-like, estrogen-regulated, growth inhibitor (RERG) is a malignant mesothelioma biomarker of clinical course and treatment sensitivity and, itself a target for mesothelioma treatment. A low RERG level in a mesothelioma subject indicates poor prognosis. Analyzing RERG expression level along can help mesothelioma patients make treatment choices. Furthermore, mesothelioma can be treated by modulating RERG activity, for example, with treatment with estrogen or estrogen-like agents.

Find Patent Forward Citations

Bueno, Raphael. (2016). Method for treatment of mesothelioma (U.S. Patent No. 9446050). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9446050

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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