The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2016
Filed:
Aug. 12, 2015
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Inventors:
Roeland Nusse, Stanford, CA (US);
Karl H. Willert, Del Mar, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C07K 14/575 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); C12N 5/074 (2010.01); C12N 5/0789 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0607 (2013.01); A61K 38/164 (2013.01); A61K 38/17 (2013.01); A61K 38/1709 (2013.01); C07K 14/47 (2013.01); C07K 14/575 (2013.01); C12N 5/0647 (2013.01); C12N 2501/415 (2013.01);
Abstract
Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.