The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2016
Filed:
Jul. 15, 2014
Applicant:
Macrogenics, Inc., Rockville, MD (US);
Inventors:
Leslie S. Johnson, Darnestown, MD (US);
Ling Huang, Bethesda, MD (US);
Paul A. Moore, North Bethesda, MD (US);
Deryk T. Loo, Belmont, CA (US);
Francine Z. Chen, San Francisco, CA (US);
Assignee:
MacroGenics, Inc., Rockville, MD (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 16/30 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); C07K 16/28 (2006.01); G01N 33/574 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61K 47/48561 (2013.01); A61K 47/48569 (2013.01); C07K 16/2809 (2013.01); C07K 16/2827 (2013.01); G01N 33/57484 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/73 (2013.01); C07K 2317/77 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.