The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2016
Filed:
Feb. 01, 2012
Applicants:
Philip A. Beachy, Ruxton, MD (US);
James K. Chen, Mountain View, CA (US);
Anssi Jussi Nikolai Taipale, Espoo, FI;
Inventors:
Philip A. Beachy, Ruxton, MD (US);
James K. Chen, Mountain View, CA (US);
Anssi Jussi Nikolai Taipale, Espoo, FI;
Assignee:
John Hopkins University School of Medicine, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/048 (2006.01); A61K 31/4355 (2006.01); A61K 31/58 (2006.01); C07D 491/10 (2006.01); C07D 519/00 (2006.01); C07J 69/00 (2006.01);
U.S. Cl.
CPC ...
C07D 491/10 (2013.01); A61K 31/4355 (2013.01); A61K 31/58 (2013.01); C07D 491/048 (2013.01); C07D 519/00 (2013.01); C07J 69/00 (2013.01);
Abstract
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.