The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 13, 2016

Filed:

Oct. 26, 2015
Applicant:

Chinese Pla General Hospital, Beijing, CN;

Inventors:

Kunlun He, Beijing, CN;

Song Li, Beijing, CN;

Wu Zhong, Beijing, CN;

Juan Liu, Beijing, CN;

Lili Wang, Beijing, CN;

Xin Li, Beijing, CN;

Guoliang Hu, Beijing, CN;

Jie Wang, Beijing, CN;

Long Long, Beijing, CN;

Junhai Xiao, Beijing, CN;

Zhibing Zheng, Beijing, CN;

Wei Li, Beijing, CN;

Ruijun Li, Beijing, CN;

Chunlei Liu, Beijing, CN;

Jie Tang, Beijing, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/403 (2006.01); A61K 31/415 (2006.01); A61K 31/18 (2006.01); A61K 31/17 (2006.01); A61K 31/381 (2006.01); A61K 31/435 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07C 335/12 (2006.01); C07D 295/21 (2006.01); C07D 333/24 (2006.01); C07D 409/12 (2006.01); C07D 295/194 (2006.01); A61K 31/4453 (2006.01); A61K 31/5375 (2006.01);
U.S. Cl.
CPC ...
A61K 31/18 (2013.01); A61K 31/17 (2013.01); A61K 31/381 (2013.01); A61K 31/435 (2013.01); A61K 31/4453 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/5375 (2013.01); A61K 31/5377 (2013.01); C07C 335/12 (2013.01); C07D 295/194 (2013.01); C07D 295/21 (2013.01); C07D 333/24 (2013.01); C07D 409/12 (2013.01);
Abstract

The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.


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