The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2016
Filed:
Mar. 10, 2013
Applicant:
Bellicum Pharmaceuticals, Inc., Houston, TX (US);
Inventors:
David Spencer, Houston, TX (US);
Wei-Chun Chang, Houston, TX (US);
Assignee:
BELLICUM PHARMACEUTICALS, INC., Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/00 (2006.01); C12N 15/63 (2006.01); C12N 9/64 (2006.01); A61K 31/4545 (2006.01); A01K 67/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6472 (2013.01); A61K 31/4545 (2013.01);
Abstract
The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer.