The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9434921 B1

PDF
Full Text
Expired
Date of Patent:
Sep. 06, 2016

Filed:

Apr. 22, 2010
Applicant:

Shoukhrat M. Mitalipov, Beaverton, OR (US);

Inventor:

Shoukhrat M. Mitalipov, Beaverton, OR (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 15/00 (2006.01); C12N 5/075 (2010.01); C12N 5/16 (2006.01); C12N 15/877 (2010.01); C12N 15/873 (2010.01); C12N 5/073 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0609 (2013.01); C12N 5/0604 (2013.01); C12N 5/16 (2013.01); C12N 15/873 (2013.01); C12N 15/8775 (2013.01); C12N 15/8776 (2013.01); C12N 2517/10 (2013.01);
Abstract

Methods are provided for producing a primate oocyte in vitro. The methods include removing nuclear DNA from a recipient primate oocyte from a first primate in a manner that does not lower levels of maturation promoting factor (MPF) to form an enucleated recipient primate oocyte. The recipient primate oocyte is enucleated using a non-UV-based spindle imaging system. Nuclear genetic material or DNA including chromosomes from a donor primate oocyte arrested at metaphase II from a second primate is isolated in the form of the karyoplast and introduced into the enucleated recipient primate oocyte. Introduction of the chromosomes is performed using a fusogenic agent or electroporation to produce a hybrid oocyte.


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Mitalipov, Shoukhrat. (2016). Methods for mitochondrial dna replacement in oocytes (U.S. Patent No. 9434921). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9434921

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