The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2016
Filed:
Dec. 10, 2010
Radovan Buffa, Humenne, SK;
Sofiane Kettou, Uherske Hradiste, CZ;
Lucie Pospisilova, Svitavy, CZ;
Gloria Huerta-angeles, Ceska Trebova, CZ;
Drahomira Chladkova, Letohrad, CZ;
Vladimir Velebny, Zamberk, CZ;
Radovan Buffa, Humenne, SK;
Sofiane Kettou, Uherske Hradiste, CZ;
Lucie Pospisilova, Svitavy, CZ;
Gloria Huerta-Angeles, Ceska Trebova, CZ;
Drahomira Chladkova, Letohrad, CZ;
Vladimir Velebny, Zamberk, CZ;
Contipro Pharma a.s., Dolni Dobrouc, CZ;
Abstract
The invention relates to a new method of preparation of a hyaluronan derivative with an aldehydic group in the position (6) of the polysaccharide glucosamine part. The hyaluronic acid oxidation can be performed by means of TEMPO/NaCIO or TEMPO/TCC systems in a protic environment with or without the presence of anorganic salts. Thus prepared aldehyde can be used for binding amines, diamines, amino acids, peptides and other compounds containing an amino group, e.g. by means of the reductive amination with NaBHCN in water or in a water-organic solvent system. When a diamine or compounds containing three or more amino groups are used, cross-linked hyaluronan derivatives can be prepared. Cross-linked derivatives can be also prepared by a reaction of the aldehyde with a hyaluronan substituted by an amino-alkyl group HA-alkyl-NH.