The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2016
Filed:
Dec. 22, 2011
Qing Xiao, Guangdong, CN;
Jian Liu, Guangdong, CN;
Hongling LI, Guangdong, CN;
Yaping MA, Guangdong, CN;
Jiancheng Yuan, Guangdong, CN;
Qing Xiao, Guangdong, CN;
Jian Liu, Guangdong, CN;
Hongling Li, Guangdong, CN;
Yaping Ma, Guangdong, CN;
Jiancheng Yuan, Guangdong, CN;
HYBIO PHARMACEUTICAL CO., LTD., Shenzhen, Guangdong, CN;
Abstract
The present invention provides a method for preparing atosiban acetate. The method comprises the following steps of: synthesizing to obtain linear atosiban; dissolving the linear atosiban in an acetonitrile aqueous solution, adjusting the pH value with ammonia water, adding HOfor oxidizing, filtering, purifying, and transferring salt to obtain the atosiban acetate. In the present invention, an appropriate route is provided, the linear atosiban is synthesized by adopting a solid phase method, and the atosiban is obtained by liquid phase oxidation. The method has the advantages of capabilities of solving the problem of insolubility of the linear atosiban, reducing the reaction size to the maximum extent and shortening reaction time, and being high in yield and easy to industrialize.