The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2016
Filed:
Dec. 19, 2014
Supernus Pharmaceuticals, Inc., Rockville, MD (US);
Likan Liang, Boyds, MD (US);
Padmanabh P. Bhatt, Rockville, MD (US);
David Dain, Baltimore, MD (US);
Jean-Philippe Taquet, Lugrin, FR;
Aleksandr Pechenov, Germantown, MD (US);
Alexei Tchesnokov, Germantown, MD (US);
Reynold Mariaux, Vionnaz, CH;
Supernus Pharmaceuticals, Inc., Rockville, MD (US);
Abstract
Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.