The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2016

Filed:

Jan. 31, 2012
Applicants:

Michael Karin, La Jolla, CA (US);

Massimo Ammirante, San Diego, CA (US);

Ali Kuraishy, San Diego, CA (US);

Inventors:

Michael Karin, La Jolla, CA (US);

Massimo Ammirante, San Diego, CA (US);

Ali Kuraishy, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61P 37/08 (2006.01); A61K 47/48 (2006.01); C07K 14/52 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61K 31/381 (2006.01); A61K 31/437 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/48376 (2013.01); A61K 31/381 (2013.01); A61K 31/437 (2013.01); A61K 38/1709 (2013.01); A61K 38/1793 (2013.01); A61K 39/395 (2013.01); C07K 14/52 (2013.01); C07K 16/24 (2013.01); C07K 16/2887 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C07K 2319/30 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01);
Abstract

The invention provides methods for reducing growth and/or metastasis of androgen-independent (castration resistant) prostate cancer in a tissue in an animal. In one embodiment the method comprises administering to the animal a therapeutically effective amount of a compound that reduces the number of B cells, and/or the function of B cells, in the tissue. In yet another embodiment, the invention provides methods for reducing androgen-induced growth of prostate epithelial cells in prostate tissue in an animal. In one embodiment, the method comprises administering to the animal a therapeutically effective amount of a compound that reduces the number of B cells, and/or the function of B cells, in the tissue.


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