The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2016
Filed:
Dec. 29, 2014
Applicant:
Nono Inc., Toronto, OT, CA;
Inventors:
Assignee:
NONO INC., , CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/02 (2006.01); A61K 47/48 (2006.01); A61K 31/275 (2006.01); A61K 38/08 (2006.01); A61K 38/10 (2006.01); A61K 45/06 (2006.01); A61K 31/277 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48315 (2013.01); A61K 31/275 (2013.01); A61K 31/277 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 45/06 (2013.01);
Abstract
The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.