The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2016

Filed:

May. 21, 2013
Applicants:

Ganymed Pharmaceuticals Ag, Mainz, DE;

Tron—translationale Onkologie an Der Universitätsmedizin Der Johannes Gutenberg-universität Mainz Gemeinnützige Gmbh, Mainz, DE;

Inventors:

Ugur Sahin, Mainz, DE;

Özlem Türeci, Mainz, DE;

Rita Mitnacht-Kraus, Friedberg, DE;

Stefan Denis Jacobs, Mainz-Kastel, DE;

Magdalena Jadwiga Utsch, Heidesheim am Rhein, DE;

Cornelia Adriana Maria Heinz, Dalheim, DE;

Christiane Regina Stadler, Bensheim, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); A01N 57/00 (2006.01); A01N 33/02 (2006.01); A01N 43/40 (2006.01); A61K 45/06 (2006.01); C07K 16/30 (2006.01); A61K 31/282 (2006.01); A61K 31/337 (2006.01); A61K 31/4375 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01); A61K 31/675 (2006.01); A61K 31/704 (2006.01); A61K 33/24 (2006.01); A61K 38/20 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61K 31/282 (2013.01); A61K 31/337 (2013.01); A61K 31/4375 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); A61K 31/675 (2013.01); A61K 31/704 (2013.01); A61K 33/24 (2013.01); A61K 38/2013 (2013.01); A61K 45/06 (2013.01); C07K 16/3046 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01);
Abstract

The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.


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