The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
Sep. 15, 2014
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Nancy P. Keller, Madison, WI (US);
Saori Amaike Campen, Madison, WI (US);
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 1/02 (2006.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01); C12N 1/00 (2006.01); C12Q 1/68 (2006.01); C12N 9/20 (2006.01); A01H 5/12 (2006.01); C12N 15/80 (2006.01); A61K 38/00 (2006.01); C12R 1/645 (2006.01);
U.S. Cl.
CPC ...
C12P 1/02 (2013.01); C12Q 1/6895 (2013.01); A01H 5/12 (2013.01); A61K 38/00 (2013.01); C12N 9/20 (2013.01); C12N 15/80 (2013.01); C12Q 2600/158 (2013.01); C12R 1/645 (2013.01);
Abstract
The invention provides a general and facile method to obtain secondary metabolites from fungal sources. The invention is based on the discovery that the fungal gene veA and protein encoded thereby regulates the activity of multiple secondary metabolite gene clusters in fungi. Over expression of the gene veA provides increased production of secondary metabolites in engineered cells. In particular, such a method of increasing secondary metabolite production allows the production of improved yields of valuable secondary metabolite products.